Biochemical Studies on Albino Rats after Administration of Nitrosamine and the Therapeutic Actions of Vitamin C, Honey Bee or Crushed Citrus Seeds

Ismael I Abdelaziz, Abd El Rahiem A Ashour


The current investigation was carried out to study the effect of administration of dibutyl nitrosamine (DBNA) precursors namely: dibutylamine (DBA) and sodium nitrite for eight weeks on some biochemical blood indices of albino rats and the therapeutic action of vitamin C (150 mg/L), honey bee (100 mg/L) or crushed citrus seeds (100 g/Kg diet) against toxicity induced by DBNA. Nitrosamine administration elevated the concentrations of serum glucose, triglycerides, total cholesterol and nonprotein nitrogenous constituents. Activities of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) were increased also significantly following DBNA treatment to rats for eight weeks, but total protein were decreased. However, honey bee, Vitamin C and crushed citrus seeds were able to modulate the affected values of the previous biochemical parameters, approximately, near to the control values. Our findings suggested that honey bee, Vitamin C and crushed citrus seeds suppresses DBNA induced hepato-renalo-carcinogenesis, maybe, by modulating the antioxidant defense status.


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