TBX3 Role in Colorectal Cancer Treatment

Abstract

The T-box family of developmentally important transcription factors has been shown to play a role in the genesis of cancer and shows much promise for a targeted therapeutic approach. For example, the T-box factor TBX3 is overexpressed in a number  of  cancers  including  colorectal cancer  but  its precise role  in  the  treatment of  this  disease  still need  to  be  clarified. We provide novel evidence to show that knocking down TBX3 sensitizes colorectal cancer cells to cisplatin treatment.