EVALUATION OF THE EFFICACY OF HEPATITIS B VACCINE IN DIFFERENT AGE GROUPS OF IMMUNIZED CHILDREN IN GAZA STRIP

Faten Elian, Mohammad E. Shubair

Abstract


The objective of this study was to evaluate the long-term
efficacy of hepatitis B virus immunization program in Gaza strip on
preventing hepatitis B virus"HBV" infection, and assesses its impact on the
incidence of hepatitis B in children.
The participants in this study were 180 children; 90 males and 90 females
categorized into three age groups (2 – 5 y), (6 – 8 y) and (9 –11 y).
Serum samples from each participant were tested for the quantitative
determination of anti-hepatitis B virus surface antigen (anti-HBs) antibody
using microparticle enzyme immunoassay (MEIA) technology as well as
immunochromatographic qualitative testing for hepatitis B surface antigen
(HBsAg).
The study showed that the efficacy of hepatitis B vaccine was 98.3%.
HBsAg was not detected in any participant. The protective level for the (2 – 5
y) and (6 – 8 y) groups were 100% while the protective level for the (9 – 11 y)
group was 95% (P ≤ 0.04). The study also showed that the efficacy of
hepatitis B vaccine was statistically significant among the three age groups (P
< 0.04), especially between (2 – 5 y) group and (9 – 11 y) group, as well as
between (2 – 5 y) group and (6 – 8 y). The results of this study revealed that
there was no significant difference between males and females for hepatitis B
vaccine efficacy (P > 0.05).
We concluded that the hepatitis B vaccine efficacy is high in
immunocompetent population and a booster dose is not necessary at least in
the studied age groups, due to the existence of an anamnestic response.

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